Pekan 6 (26 September 2021)
Inter vs Atalanta
Lazio vs AS Roma
Pekan 7 (3 Oktober 2021)
Atalanta vs Milan
Pekan 8 (17 Oktober 2021)
Juventus vs AS Roma
Lazio vs Inter
Pekan 9 (24 Oktober 2021)
Inter vs Juventus
AS Roma vs Napoli
Pekan 11 (31 Oktober 2021)
Atalanta vs Lazio
AS Roma vs Milan
Pekan 12 (7 November 2021)
Milan vs Inter
Pekan 13 (21 November 2021)
Inter vs Napoli
Lazio vs Juventus
Pekan 14 (28 November 2021)
Juventus vs Atalanta
Napoli vs Lazio
Pekan 16 (5 Desember 2021)
Napoli vs Atalanta
AS Roma vs Inter
Pekan 18 (19 Desember 2021)
Milan vs Napoli
Pekan 20 (6 Januari 2022)
Juventus vs Napoli
Milan vs AS Roma
Pekan 21 (9 Januari 2022)
Inter vs Lazio
AS Roma vs Juventus
Pekan 22 (16 Januari 2022)
Atalanta vs Inter
Pekan 23 (23 Januari 2022)
Lazio vs Atalanta
Milan vs Juventus
Pekan 24 (6 Februari 2022)
Inter vs Milan