Metalist Kharkiv 4-1 Salzburg (agregat 8-1)
Gol: Martin Hinteregger 28 (og), Jonathan Cristaldo 62, Sebastian Blanco 63, Bonfim Marlos 87; Jakob Jantscher 56
Olympiakos 1-0 Rubin Kazan (agregat 2-0)
Gol: Rafik Djebbour 14
Anderlecht 0-1 AZ Alkmaar (agregat 0-2)
Gol: Maarten Martens 54
Atletico Madrid 1-0 Lazio (agregat 4-1)
Gol: Diego Godin 48
Manchester United 1-2 Ajax (agregat 3-2)
Gol: Javier Hernandez 6; Aras Ozbiliz 37, Toby Alderweireld
Schalke 3-1 Viktoria Plzen (agregat 4-2)
Gol: Klaas-Jan Huntelaar 8, 106, 120; Rajtoral 88