Berikut adalah hasil lengkap putaran kedua Piala Liga Inggris musim 2021-2022:
Rabu (25/8/2021)
Oldham Athletic 5-4 Accrington (penalti)
Swansea 4-1 Plymouth Argyle
Norwich 6-0 Bournemouth
Northampton 0-1 AFC Wimbledon
Blackpool 2-3 Sunderland
Birmingham 0-2 Fulham
Cardiff 0-2 Brighton
Shrewsbury 0-2 Rochdale
Gillingham 4-5 Cheltenham (penalti)
Millwall 3-1 Cambridge United
Wigan 5-4 Bolton (penalti)
Barrow 0-6 Aston Villa
Stevenage 3-5 Wycombe (penalti)
QPR 2-0 Oxford United
Morecambe 2-4 Preston North End
Sheffield United 2-1 Derby County
Brentford 3-1 Forest Green
Huddersfield 1-2 Everton
Watford 1-0 Crystal Palace
Stoke City 2-0 Doncaster
Leeds United 3-0 Crewe
Nottingham Forest 0-4 Wolves
Kamis (26/8/2021)
Newcastle 3-4 Burnley (penalti)
Newport 0-8 Southampton
West Brom 0-6 Arsenal